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Frontiers | Murine Models of Acute Myeloid Leukemia
Frontiers | Murine Models of Acute Myeloid Leukemia

Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses  malignant gene expression and tumor growth
Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth

MLL-AF9 initiates transformation from fast-proliferating myeloid  progenitors | Nature Communications
MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors | Nature Communications

Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL -AF9-Driven AML - ScienceDirect
Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL -AF9-Driven AML - ScienceDirect

iMLL-AF9: Modeling MLL-AF9-Dependent AML | Download Scientific Diagram
iMLL-AF9: Modeling MLL-AF9-Dependent AML | Download Scientific Diagram

Histone H3K36me2-specific methyltransferase ASH1L is required for the MLL- AF9-induced leukemogenesis | bioRxiv
Histone H3K36me2-specific methyltransferase ASH1L is required for the MLL- AF9-induced leukemogenesis | bioRxiv

The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse  Models. - Abstract - Europe PMC
The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models. - Abstract - Europe PMC

Iron metabolism in the MLL-AF9 AML mouse model. (A) MLL-AF9 1 AML cells...  | Download Scientific Diagram
Iron metabolism in the MLL-AF9 AML mouse model. (A) MLL-AF9 1 AML cells... | Download Scientific Diagram

Protocol to establish a stable MLL-AF9_AML mouse model
Protocol to establish a stable MLL-AF9_AML mouse model

Establishment of the LARP4B knockdown MLL-AF9 AML mouse model. ( A )... |  Download Scientific Diagram
Establishment of the LARP4B knockdown MLL-AF9 AML mouse model. ( A )... | Download Scientific Diagram

Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL- AF9-Initiated Leukemia - ScienceDirect
Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL- AF9-Initiated Leukemia - ScienceDirect

CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven  Acute Myeloid Leukemia - ScienceDirect
CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia - ScienceDirect

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML  Expressing EMT-Related Genes Linked to Poor Outcome - ScienceDirect
MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome - ScienceDirect

P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by  upregulation of Pbx3 | Haematologica
P2X7 promotes the progression of MLL-AF9 induced acute myeloid leukemia by upregulation of Pbx3 | Haematologica

Cancers | Free Full-Text | Pathways, Processes, and Candidate Drugs  Associated with a Hoxa Cluster-Dependency Model of Leukemia
Cancers | Free Full-Text | Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

The Mll-AF9 knockin mouse model. Homologous recombination was used in... |  Download Scientific Diagram
The Mll-AF9 knockin mouse model. Homologous recombination was used in... | Download Scientific Diagram

Integrated transcriptomic and epigenetic data analysis identifiesaberrant  expression of genes in acute myeloid leukemia with MLL‑AF9 translocation  Corrigendum in /10.3892/mmr.2021.12295
Integrated transcriptomic and epigenetic data analysis identifiesaberrant expression of genes in acute myeloid leukemia with MLL‑AF9 translocation Corrigendum in /10.3892/mmr.2021.12295

JCI - MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell  self-renewal requires JMJD1C
JCI - MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

The Mll–AF9 gene fusion in mice controls myeloproliferation and specifies  acute myeloid leukaemogenesis | The EMBO Journal
The Mll–AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis | The EMBO Journal

JCI - MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell  self-renewal requires JMJD1C
JCI - MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine  acute myeloid leukemia | Journal of Hematology & Oncology | Full Text
Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia | Journal of Hematology & Oncology | Full Text

LAIR1 enhances development of MLL-AF9 mouse AML during serial... | Download  Scientific Diagram
LAIR1 enhances development of MLL-AF9 mouse AML during serial... | Download Scientific Diagram

expression of Mb(S4) in MLL-AF9 cells inhibits leukemia progression... |  Download Scientific Diagram
expression of Mb(S4) in MLL-AF9 cells inhibits leukemia progression... | Download Scientific Diagram

Polycomb repressive complex 2 is required for MLL-AF9 leukemia | PNAS
Polycomb repressive complex 2 is required for MLL-AF9 leukemia | PNAS

IJMS | Free Full-Text | CRISPR Gene Editing of Murine Blood Stem and  Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9  Leukaemogenesis
IJMS | Free Full-Text | CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis